The article provides an overview of the various roster designations in the NFL, including Injured Reserve (IR), Physically Unable to Perform (PUP), and Non-Football Injury (NFI). It explains how these designations affect player eligibility, roster limits, and team strategies throughout the season. Understanding these designations is crucial for fans and fantasy football players alike, as they impact player availability and team dynamics.

• IR allows players to be sidelined for at least four games without counting against the active roster.
• PUP players can participate in team activities but not practice, and they count against the roster limit.
• NFI is for injuries not related to football, allowing teams to manage player health effectively.