San Francisco 49ers running back Isaac Guerendo is set to return to action against the Detroit Lions after missing a game due to a hamstring injury. Guerendo had stepped up as a starter due to multiple injuries in the backfield, showcasing his potential with a solid performance against the Chicago Bears. His return comes at a crucial time for the 49ers as they navigate through a challenging injury situation at the running back position.
- Issac Guerendo's return will bolster the 49ers' running game.
- The 49ers have faced significant injuries in their backfield this season.