The San Francisco 49ers are preparing for an unusually hot game against the Arizona Cardinals, with temperatures expected to reach 99 degrees, making it the hottest game in Levi's Stadium history. Coach Kyle Shanahan expressed concern over the heat and the team's hydration strategies, including a change in uniform to help combat the heat. The 49ers have ruled out two players and have several others listed as questionable, including key players Fred Warner and George Kittle.

• The 49ers are adapting their uniform strategy due to extreme heat.
• Hydration is a major focus for the team as they prepare for the game.