San Francisco 49ers tight end George Kittle has been officially ruled out for the upcoming game against the Los Angeles Rams due to a hamstring injury. Initially listed as doubtful, Kittle's absence is a significant blow to the 49ers' offense, which will also be missing key players Christian McCaffrey and Deebo Samuel. In Kittle's absence, Eric Saubert is expected to start at tight end, with Jake Tonges potentially seeing more targets.

• George Kittle's injury severely impacts the 49ers' offensive strategy.
• Eric Saubert and Jake Tonges will need to step up in Kittle's absence.