The San Francisco 49ers will be without several key defensive players for their game against the Arizona Cardinals. Tackles Arik Armstead and Javon Hargrave, linebackers Dre Greenlaw and Oren Burks, and cornerback Charvarius Ward are all potentially missing from the lineup. Armstead, Hargrave, and Burks have been ruled out, while Greenlaw and Ward are listed as questionable. The Niners will rely on Javon Kinlaw and Kevin Givens to step in for Armstead and Hargrave, with Kalia Davis providing depth. Demetrius Flannigan-Fowles is the backup for Burks. The 49ers need a win against the Cardinals to secure the NFC West division title.

• The 49ers will be missing several key defensive players for their game against the Cardinals.
• Tackles Arik Armstead and Javon Hargrave, linebackers Dre Greenlaw and Oren Burks, and cornerback Charvarius Ward are potentially out.
• Javon Kinlaw and Kevin Givens will step in for Armstead and Hargrave.
• Demetrius Flannigan-Fowles is the backup for Burks.
• The 49ers need a win against the Cardinals to secure the NFC West division title.