49ers quarterback Brock Purdy is dealing with a right shoulder injury but managed to participate in a limited practice on Wednesday. As the team prepares for their upcoming game against the Bills, his progress will be closely monitored. Given the tough matchup against a strong defense, Purdy may not be a recommended QB1 option this week.

• Brock Purdy's shoulder injury is a concern for his fantasy value.
• The Bills present a challenging matchup for quarterbacks.