The San Francisco 49ers scored their first defensive touchdown of the season with a 66-yard interception return by cornerback Charvarius Ward. This gave the 49ers their first lead of the game against the Arizona Cardinals. Deebo Samuel also scored a touchdown earlier in the game, making it his seventh in the past four games.

• The 49ers scored their first defensive touchdown of the season with a 66-yard interception return by Charvarius Ward.
• Deebo Samuel scored his seventh touchdown in the past four games.
• If Samuel scores a rushing touchdown in this game, he would join Pete Johnson as the only players in NFL history to score a receiving and rushing touchdown in three consecutive games.