Titans DT Jeffery Simmons will miss his third straight game against the Seahawks, which is a big blow to the run defense. Tennessee has also ruled out several other defensive players, making it a favorable matchup for the Seattle offense.

• Titans DT Jeffery Simmons will miss his third straight game against the Seahawks.
• Tennessee's run defense has struggled without Simmons in the past two weeks.
• Tennessee has also ruled out S Amani Hooker, S K'Von Wallace, LB Jack Gibbens, and CB Sean Murphy-Bunting.
• The matchup is favorable for the Seattle offense.