Colts wide receiver Michael Pittman is facing a significant setback as he is expected to miss multiple weeks due to a back injury sustained during the Week 5 loss to the Jaguars. Reports indicate that he did not practice on Wednesday, and there is a possibility that he may be placed on injured reserve. Further updates on his condition and recovery timeline are anticipated.

• Michael Pittman's absence will impact the Colts' passing game significantly.
• Injured reserve is a possibility, indicating the severity of the injury.