San Francisco 49ers wide receiver Brandon Aiyuk, who was medically cleared to practice, was absent from Wednesday's session, raising concerns about his ongoing contract dispute. Aiyuk had previously been a 'hold in' due to back and neck soreness, allowing him to avoid fines during training camp. However, with the regular season approaching, the team may impose fines for his absence. The 49ers are also dealing with left tackle Trent Williams' holdout as they prepare for the season opener against the New York Jets.

• Brandon Aiyuk's absence from practice despite being medically cleared raises questions about his contract situation.
• The 49ers may impose fines on Aiyuk for missing practices as the regular season begins.
• Trent Williams is also holding out, adding to the 49ers' challenges as they prepare for Week 1.