The Seattle Seahawks will be without their top edge defender, Uchenna Nwosu, for their upcoming game against the San Francisco 49ers. Nwosu, who recently returned from an MCL sprain, suffered a thigh injury during the Seahawks' loss to the New York Giants. Additionally, rookie defensive tackle Byron Murphy II is also unlikely to play due to a hamstring injury. The Seahawks are struggling with injuries as they aim to break a five-game losing streak against the 49ers.

• The Seahawks are facing significant injury challenges as they prepare for a crucial divisional matchup.
• Nwosu's absence will be a major blow to Seattle's defense against a strong 49ers offense.