Joe Mixon is not expected to play in Week 5 due to an ankle injury, marking his third consecutive absence. Despite his absence, head coach continues to label him as 'day-to-day.' Mixon had previously trained intensely for a heavy workload this season with the Texans, following his move from the Bengals. With Dameon Pierce also dealing with a hamstring issue, the Texans' backfield will likely be led by Cam Akers and Dare Ogunbowale against the Bills.
- Mixon's absence will impact the Texans' running game significantly.
- The Texans may rely on less experienced backs in Mixon's absence.