The Seattle Seahawks will be missing several key defensive players for their upcoming game against the San Francisco 49ers. Pro Bowl cornerback Riq Woolen, outside linebacker Uchenna Nwosu, and defensive tackle Byron Murphy II have all been ruled out. Coach Mike Macdonald provided updates on the injuries, indicating that Nwosu is headed to injured reserve and that Woolen's status remains uncertain. The Seahawks hope to have their other top outside linebackers available, while safety Julian Love is listed as questionable.

• The Seahawks will be without three key defenders against the 49ers.
• Nwosu is expected to be sidelined for more than four games after going to injured reserve.
• Woolen's ankle injury status is uncertain, but he is not ready to play.