Joe Mixon has been ruled out for the upcoming game against the Bills due to an ankle injury. He was unable to practice this week and is targeting a return on October 13 against the Patriots. Meanwhile, Dameon Pierce's status is questionable, which could impact the Texans' backfield dynamics.
- Joe Mixon is sidelined for Week 5 due to an ankle injury.
- Mixon's absence may lead to increased opportunities for other running backs in the Texans' lineup.