San Francisco 49ers head coach Kyle Shanahan announced that running back Christian McCaffrey will be sidelined for the remainder of the regular season due to a PCL injury in his right knee. Additionally, running back Jordan Mason is set to go on injured reserve with a high-ankle sprain, further depleting the team's backfield options as they head into the final stretch of the season.
- McCaffrey's absence will significantly impact the 49ers' offensive strategy.
- The loss of Mason adds to the challenges for the team's running game.