In a tough opening game against the Buffalo Bills, Kyler Murray struggled with his passing numbers, completing 21 of 31 passes for 162 yards and one touchdown. Despite a strong start, the Arizona Cardinals ultimately fell to the Bills 34-28. Murray's performance included a fumble that contributed to the team's loss. Additionally, he will be without new receiver Zay Jones for the first five games of the season due to suspension, which could impact his passing game moving forward.

• Murray had a solid start but struggled to maintain momentum.
• The loss of Zay Jones for five games could hinder Murray's passing options.