Jonathan Taylor, the Colts' star running back, did not practice on Wednesday due to a mild high-ankle sprain, making him unlikely to participate in the upcoming game against the Jaguars. In Taylor's absence, Trey Sermon is expected to step up as the lead back, with Tyler Goodson serving as the backup. Sermon is currently ranked as an RB3 for Week 4.
- Jonathan Taylor's injury could significantly impact the Colts' running game.
- Trey Sermon is a viable option for fantasy teams as he steps into the lead role.