Keon Coleman, the rookie wide receiver for the Buffalo Bills, has been ruled inactive for the Sunday night game against the San Francisco 49ers due to a wrist injury. This marks his second consecutive game missed after sustaining the injury in Week 9. Despite being listed as limited in practice, he was ultimately unable to participate, leaving the Bills to rely on other wideouts for the matchup.

• Keon Coleman continues to struggle with a wrist injury, missing multiple games.
• The Bills will rely on other receivers like Amari Cooper and Khalil Shakir in Coleman's absence.