San Francisco 49ers running back Jordan Mason is dealing with a shoulder injury and was limited in practice on Wednesday. Head coach Kyle Shanahan has indicated that Mason is 'day to day' with a sprained AC joint, making his availability for the upcoming game against the Kansas City Chiefs uncertain. If Mason is unable to play, rookie Isaac Guerendo would step up as the lead back against a formidable Chiefs defense.
- Jordan Mason's injury status is critical for fantasy managers.
- If Mason is out, Isaac Guerendo could be a valuable pickup.
Jordan Mason | RB

Injury
Week 5
- Limited in practice due to a shoulder injury.
- Considered day to day, making him questionable for the game.
Isaac Guerendo | RB

Pickup
Breakout
Week 5
- Could become the lead back if Mason is ruled out.
- Rookie status may present both risk and opportunity.
San Francisco 49ers

- Need to monitor Mason's injury closely.
- Potential for Guerendo to emerge as a fantasy option.
Kansas City Chiefs

- Ranked as the top defense against running backs.
- Will pose a significant challenge for whoever plays RB for the 49ers.