San Francisco 49ers running back Christian McCaffrey suffered a knee injury during the Sunday Night Football game against the Buffalo Bills. He was seen limping off the field after a toss play in the second quarter and was taken to the locker room for evaluation. Prior to the injury, McCaffrey had a solid performance, rushing for 53 yards and catching 14 yards worth of passes. With McCaffrey's status uncertain, the 49ers will rely on backup running backs Jordan Mason and Isaac Guerendo moving forward.
- McCaffrey's injury could significantly impact the 49ers' offense.
- Backup running backs Jordan Mason and Isaac Guerendo will need to step up.