San Francisco 49ers wide receiver Brandon Aiyuk is believed to have suffered a season-ending knee injury, likely a torn ACL, during a game against the Kansas City Chiefs. Aiyuk's injury occurred when he was hit by two defenders, leading to significant concern regarding his availability for the remainder of the 2024 season. The 49ers will need to adjust their offensive strategy as Aiyuk was a key player before his injury.

• Brandon Aiyuk is likely done for the 2024 season due to a knee injury.
• Deebo Samuel and George Kittle will see increased target shares in Aiyuk's absence.
• The 49ers may rely on other receivers like Jauan Jennings, Ricky Pearsall, Jacob Cowing, and Chris Conley.