49ers quarterback Brock Purdy is listed as questionable for the upcoming game against the Bills due to a shoulder injury. However, after participating in a full practice on Friday, head coach Kyle Shanahan expressed optimism about Purdy's availability, stating that he is currently on track to play. Despite this positive news, the matchup against Buffalo's strong defense and San Francisco's low implied point total suggest that Purdy may not be a viable QB1 option this week.

• Purdy's shoulder injury raises concerns for his performance.
• Buffalo's defense is a tough matchup for quarterbacks.
• San Francisco's low implied points indicate a challenging game ahead.