In a high-scoring matchup against the Buffalo Bills, the Detroit Lions suffered significant injuries to their defense, impacting their performance. Cornerback Khalil Dorsey was carted off the field after a concerning injury, while starting defensive tackle Alim McNeill was ruled out with a knee injury. Additionally, cornerback Carlton Davis III was also downgraded to out due to a jaw injury. These injuries compounded the Lions' struggles as they fell to the Bills with a final score of 48-42.

• The Lions' defense is facing significant challenges with multiple key injuries.
• Khalil Dorsey's injury raises concerns about the team's depth in the secondary.