San Francisco 49ers running back Isaac Guerendo is expected to miss the upcoming game against the Miami Dolphins due to a hamstring injury. This season has been challenging for the 49ers' running back depth chart, which has been severely impacted by injuries to key players like Christian McCaffrey, Jordan Mason, and Elijah Mitchell. With Guerendo's absence, the 49ers will rely on other running backs on their roster, including Patrick Taylor Jr. and Israel Abanikanda.
- Isaac Guerendo's injury leaves the 49ers' backfield in a precarious position.
- The team has been significantly impacted by injuries this season.