In a dominant performance, the Arizona Cardinals defeated the Los Angeles Rams 41-10, with rookie wide receiver Marvin Harrison Jr. making headlines by scoring his first two career touchdowns in the first quarter. Harrison's explosive start included four catches for 130 yards, making him one of the few rookies to achieve such a feat. Quarterback Kyler Murray also shined, completing 17 of 21 passes for 266 yards and three touchdowns, while running back James Conner contributed significantly with 122 rushing yards and a touchdown.
- Marvin Harrison Jr. had a record-setting first quarter with 130 yards and two touchdowns.
- Kyler Murray achieved a perfect passer rating and contributed significantly in both passing and rushing.
- James Conner extended his touchdown streak to seven games.