The Buffalo Bills will face the Houston Texans without several key players, including wide receiver Khalil Shakir and defensive tackles Ed Oliver and Austin Johnson, along with safety Taylor Rapp. Coach Sean McDermott confirmed these absences due to injuries sustained in practice and games. The Bills will rely on rookie Cole Bishop to start in Rapp's place, while other defensive players are also dealing with injuries.
- The Bills are facing significant injury challenges ahead of their game against the Texans.
- Rookie Cole Bishop will have a chance to prove himself in his first NFL start.