Isaac Guerendo, a running back for the San Francisco 49ers, is expected to return for Week 17 after missing Week 16 due to a hamstring injury. Despite being limited in practice, he is anticipated to take on a lead role in the backfield, following a productive stretch in Weeks 14 and 15 where he totaled 203 yards from scrimmage and two rushing touchdowns.

• Isaac Guerendo is expected to play in Week 17 against the Lions.
• He was limited in practice due to foot and hamstring injuries but is likely to take on a lead role.