The Buffalo Bills faced a disappointing 33-6 loss to the Chicago Bears in their preseason opener, highlighting significant areas for improvement. Head coach Sean McDermott expressed frustration over the team's performance, particularly in the offensive line and running game, which struggled to gain traction. Despite some positives, including kicker Tyler Bass's performance and an early standout by the red zone defense, McDermott emphasized the need for the team to embrace the challenges ahead.

• Buffalo Bills struggled significantly in their preseason opener against the Bears.
• Head coach Sean McDermott highlighted the need for improvement in multiple areas, especially offensive line and running game.