Colts wide receiver Alec Pierce will miss the upcoming game against the Tennessee Titans due to a concussion he sustained during last week's loss to the Denver Broncos. Pierce, who leads the team in receiving yards and touchdowns, leaves a significant gap in the Colts' receiving corps. His absence will allow rookie Adonai Mitchell to take on a larger role, while backup Ashton Dulin may also contribute if he returns from an ankle injury. Additionally, linebacker E.J. Speed will miss the game due to a knee injury.

• Alec Pierce's absence is a significant blow to the Colts' passing game.
• Rookie Adonai Mitchell will need to step up in Pierce's absence.