San Francisco 49ers wide receiver Deebo Samuel has been confirmed out for Week 3 against the Rams due to a calf injury sustained in Week 2. With key players like Christian McCaffrey and George Kittle also dealing with injuries, the 49ers are facing a challenging situation in their skill positions. Samuel's absence is expected to be felt as the team looks to other players to step up in his place.

• Deebo Samuel is out for Week 3 due to a calf injury.
• The 49ers are dealing with multiple injuries to key offensive players.
• Expect increased roles for Brandon Aiyuk and Jauan Jennings in Samuel's absence.