The Seattle Seahawks will be missing several key defensive players, including Pro Bowl cornerback Riq Woolen, outside linebacker Uchenna Nwosu, and defensive tackle Byron Murphy II, for their upcoming game against the San Francisco 49ers. Coach Mike Macdonald confirmed that Nwosu will be placed on injured reserve, while Woolen's status remains uncertain. The team is hopeful for the return of other key players, but the absence of these defenders could impact their performance against a strong 49ers team.

• Seahawks will be without key defensive starters against the 49ers.
• Nwosu is expected to miss more than four games after being placed on injured reserve.
• Woolen's status is uncertain, but he is not ready to play.