San Francisco 49ers wide receiver Deebo Samuel has been ruled out for Monday Night Football due to a hairline fracture in his shoulder. He will also miss the following game and will be reevaluated after the bye week. Left tackle Trent Williams is listed as doubtful for Monday's game due to a sprained right ankle, while running back Christian McCaffrey is listed as questionable but has made progress in practice. If Williams can't play, Jaylon Moore is expected to take his place.

• Deebo Samuel has a hairline fracture in his shoulder and will miss the next two games.
• Trent Williams is doubtful for Monday's game with a sprained ankle.
• Christian McCaffrey is questionable but has made progress in practice.
• If Williams can't play, Jaylon Moore is expected to start at left tackle.