Los Angeles Chargers safety Derwin James will miss the upcoming game against the Kansas City Chiefs due to a one-game suspension upheld by the NFL for repeated violations of playing rules. This decision follows a recent unnecessary roughness penalty during a game against the Pittsburgh Steelers. The Chargers are also facing potential absences of key players including quarterback Justin Herbert and offensive tackles Joe Alt and Rashawn Slater.

• Derwin James' suspension highlights the NFL's stance on player safety and repeated rule violations.
• The Chargers are facing significant injuries to key players ahead of their game against the Chiefs.