In a high-stakes matchup against the Buffalo Bills, Patrick Mahomes threw for three touchdowns but also recorded two costly interceptions, leading to the Kansas City Chiefs' first loss of the season. Despite the defeat, Mahomes has shown consistency with three touchdown passes in two of his last three games. This game marked a notable shift as it was his first without a rushing attempt in 2024, raising questions about his mobility moving forward. The Chiefs are set to face a favorable matchup against the Carolina Panthers next week.

• Mahomes continues to be a strong fantasy option despite the loss.
• His performance against the Panthers next week could be a bounce-back opportunity.