Christian McCaffrey has been ruled inactive for the San Francisco 49ers' Week 1 matchup against the New York Jets due to a calf/Achilles injury. This marks a significant absence for the 49ers as they will rely on Jordan Mason and others in the backfield. McCaffrey had previously expressed confidence in his ability to play, but ultimately will not take the field.
- McCaffrey's injury status is a concern for fantasy managers.
- The 49ers will need to adjust their game plan without their star running back.