San Francisco 49ers tight end George Kittle has been ruled out for the upcoming game against the Los Angeles Rams due to a hamstring injury. Kittle's absence comes alongside injuries to running back Christian McCaffrey and receiver Deebo Samuel, forcing the 49ers to adjust their lineup significantly. Tight end Eric Saubert is expected to start in Kittle's place, with additional depth provided by Brayden Willis and Sam Okuayinonu from the practice squad.
- George Kittle's absence will impact the 49ers' offensive strategy against the Rams.
- Eric Saubert is expected to step up in Kittle's role, having shown consistency in previous games.