The San Francisco 49ers are facing a challenging situation as Edge rusher Nick Bosa is expected to miss his third consecutive game due to hip and oblique injuries. Officially listed as doubtful, Bosa has not participated in any practices this week, raising concerns about his recovery and impact on the team's defense. With only one practice appearance since Week 10, the 49ers will need to adjust their defensive strategy in his absence.

• Nick Bosa's absence could significantly impact the 49ers' defensive performance.
• The team has struggled without their star edge rusher, who has been a key player in their defense.