49ers wide receiver Deebo Samuel did not practice on Wednesday due to a calf injury. Head coach Kyle Shanahan indicated last week that Samuel is expected to miss a couple of weeks, making his availability for the upcoming game against the Patriots unlikely. Updates will follow if there are any changes to his Week 4 status.

• Deebo Samuel is unlikely to play in Week 4 due to a calf injury.
• Head coach Kyle Shanahan's comments suggest a multi-week absence.