The San Francisco 49ers are facing a significant injury crisis as they prepare to cope with the loss of wide receiver Brandon Aiyuk, who will undergo surgery and be placed on injured reserve. Key players such as Christian McCaffrey, Deebo Samuel, and others are also dealing with injuries, leaving the team struggling to maintain its competitive edge. Tight end George Kittle and linebacker Fred Warner emphasize the need for the remaining players to step up and focus on their roles as they navigate this challenging period.

• The 49ers are facing a critical injury crisis, with multiple key players on injured reserve.
• Brandon Aiyuk's absence will require significant adjustments in the team's receiving corps.
• The team's depth will be tested as they look to remain competitive amidst injuries.