Kansas City Chiefs running back Isiah Pacheco has been ruled out for Sunday's game against the Bills due to a shoulder injury. Head coach Andy Reid mentioned that Pacheco could potentially be placed on injured reserve. In Pacheco's absence, Clyde Edwards-Helaire and Jerick McKinnon will handle the backfield duties. La'Mical Perine, Deneric Prince, and Keontay Ingram are on the practice squad. Edwards-Helaire is expected to handle the majority of carries, while McKinnon will be involved in the passing game and may also see some carries.