San Francisco 49ers running back Christian McCaffrey is set to miss the entire preseason due to a strained calf. Coach Kyle Shanahan indicated that McCaffrey is likely to be sidelined for a couple of weeks but should be ready for the season opener against the New York Jets. The injury comes as the 49ers also deal with injuries to other running backs, including Elijah Mitchell and rookie Isaac Guerendo. In response, the team has signed former 49ers running back Matt Breida to bolster their depth at the position.
- McCaffrey's calf injury will keep him out of the preseason, but he is expected to be ready for the regular season.
- The 49ers are facing a running back shortage with multiple injuries.
- Matt Breida has been signed to help fill the gap in the backfield.
Christian McCaffrey | RB

Injury
Week 1
- Likely to miss the entire preseason due to a strained calf.
- Expected to be ready for the season opener against the Jets.
Elijah Mitchell | RB

Injury
Week 1
- Missed the past two practices due to a strained hamstring.
- Expected to miss about a week.
Matt Breida | RB
Pickup
Week 1
- Signed to the team to provide depth at running back.
- Previously played for the 49ers from 2017 to 2019.
San Francisco 49ers

- Dealing with multiple injuries in the running back position.
- Signed Matt Breida to help with depth ahead of the preseason.