San Francisco 49ers quarterback Brock Purdy is expected to return for the game against the Buffalo Bills after recovering from a right shoulder injury. Coach Kyle Shanahan indicated that Purdy has made significant progress and is likely to play unless there are unforeseen setbacks. However, the 49ers will be without key players including left tackle Trent Williams and defensive end Nick Bosa due to injuries. Cornerback Charvarius Ward is set to return after a personal absence.

• Brock Purdy's return is crucial for the 49ers' offense.
• The absence of Trent Williams and Nick Bosa will impact the team's performance.