San Francisco 49ers running back Christian McCaffrey has been ruled inactive for the game against the New York Jets due to a calf injury. Despite testing the injury prior to the game, McCaffrey reported discomfort, leading the team to prioritize caution. This marks a significant development as McCaffrey has been dealing with this injury since early August, indicating that it may be more serious than initially communicated.

• McCaffrey's calf injury continues to be a concern, leading to his inactivity.
• The 49ers are taking a cautious approach with McCaffrey's health.