In a disappointing performance, the 49ers' offense struggled to find rhythm against the Bills, with tight end George Kittle being a notable underperformer. Kittle was targeted only twice, catching one pass for a mere seven yards, and he also dropped a key screen pass. This lack of production highlights the overall struggles of the 49ers' offensive unit during the game.

• The 49ers' offense faced significant challenges against the Bills.
• George Kittle's performance was below expectations, contributing to the team's struggles.