The Houston Texans are facing significant injury concerns in their backfield ahead of their matchup against the Buffalo Bills. Joe Mixon has been ruled out due to an ankle injury, while Dameon Pierce is questionable after a limited practice. The uncertainty surrounding Pierce's status could lead to a tough decision for fantasy managers, especially if he is unable to play.

• Joe Mixon is officially out for the game against the Bills.
• Dameon Pierce's limited practice raises questions about his availability.
• Fantasy managers should be cautious with the Texans' backfield.