In a decisive victory against the Jets, James Cook rushed for 53 yards and scored his 15th rushing touchdown of the season. Despite a dip in yardage compared to his previous performances, Cook's contribution was significant in securing the Bills' win. With the Bills already clinching the No. 2 seed, there are questions about his usage in the upcoming game against the Patriots, as they may opt to rest their starters.
- James Cook scored his 15th rushing touchdown of the season.
- Buffalo may rest starters in Week 18, affecting Cook's playing time.