Buffalo Bills wide receiver Khalil Shakir has been ruled out for Week 5 against the Texans due to an ankle injury. Coach Sean McDermott confirmed that Shakir did not practice leading up to the game and is targeting a return on October 14 against the Jets. In his absence, several other receivers will step up for the Bills.

• Khalil Shakir's absence will impact the Bills' receiving corps in Week 5.
• Shakir set a record for the most consecutive targets caught by an NFL wide receiver.