The Indianapolis Colts have placed Pro Bowl defensive tackle DeForest Buckner on injured reserve due to a right high ankle sprain. This injury is a significant setback for a Colts defense that has struggled against the run, allowing the most rushing yards in the league so far this season. Buckner will miss at least four games, marking the longest absence of his career, as he has been a key player for the Colts since joining the team in 2020.

• DeForest Buckner's injury is a major blow to the Colts' defense.
• The Colts have struggled against the run, allowing 474 rushing yards in two games.
• Buckner has been a durable player throughout his career, missing only one game prior to this injury.