The Indianapolis Colts have placed Pro Bowl defensive tackle DeForest Buckner on injured reserve due to a right high ankle sprain, marking a significant blow to their already struggling defense. Buckner will miss at least four games, which is the longest absence of his career. The Colts' defense has struggled against the run, allowing the most rushing yards in the league over the first two games of the season.

• DeForest Buckner's injury is a significant setback for the Colts' defense.
• The Colts have allowed the most rushing yards in the league so far this season.