Isaac Guerendo, running back for the San Francisco 49ers, is dealing with a hamstring injury that has sidelined him from practice. This comes after he played through a foot injury in a recent game against the Rams. With key players like Christian McCaffrey and Jordan Mason on injured reserve, the 49ers are taking a cautious approach with Guerendo's health as they prepare for their upcoming matchup against the Dolphins.

• Issac Guerendo's hamstring injury raises concerns for the 49ers' backfield depth.
• With McCaffrey and Mason out, the team may need to rely on less experienced players.